The Sleep-Gut Microbiome Connection: Unlocking the Power of Restful Sleep


By: Dr. Shaina Cahill, Ph.D. (Director Medical Communications & Affairs)

Sleep often takes a backseat in our busy lives, with many underestimating the importance of a good night’s sleep. However, emerging research highlights the remarkable link between sleep and the gut microbiome 1–4. In this blog, we will explore the fascinating relationship between sleep and the gut microbiome and learn how sleep quality, sleep deprivation, and disrupted sleep schedules can impact the composition and quality of our gut microbiota.

Sleep Quality and a Healthy Gut Microbiome:

Did you know that quality sleep is vital for maintaining a healthy gut microbiome? People who experience poor sleep quality exhibit a less diverse gut microbiome than those who enjoy restful sleep 3–7. Reduced diversity in the gut microbiome has been linked to various health conditions such as obesity, inflammatory bowel diseases, and mental health disorders like depression and anxiety2,8–16.

Why does sleep quality matter? Sleep plays a vital role in restoring our bodies, regulating inflammation, the immune system and repairing damaged tissues 3,4,6,7,14,17,18. When we experience disrupted or inadequate sleep, these essential functions can be compromised, leading to a dysregulated gut microbiome 5,17. This dysregulation of the gut can disrupt the delicate harmony between beneficial and harmful bacteria, which may contribute to gut-related disorders1,3–6,17,19,20.

Influence of Sleep on Gut Microbiome Composition:

Studies have shown that sleep can directly impact the makeup of our gut microbiome. Researchers have observed changes in the levels of specific bacterial species in response to sleep disruption 1,3–6,17,19,20. For instance, decreased sleep duration has been associated with increased levels of Enterobacteriaceae—a family of bacteria linked to inflammation and gut permeability issues 21,22. These imbalances in the gut microbiome can compromise the gut’s ability to perform vital functions, resulting in things such as digestive problems and a weakened immune system 2,8–13,15,23–25

The Impact of Reduced Sleep Hours and Shifted Schedules

: In today’s busy world, many individuals experience sleep deprivation due to shortened sleep hours or irregular sleep schedules. A chronic lack of sleep and sleep disturbances can have serious consequences for the gut microbiome5,18,20,22,26. A new scientific study reported that even a single night of sleep deprivation could immediately increase the abundance of gut bacteria associated with obesity and metabolic disturbances22,27.Shift work, characterized by irregular sleep-wake patterns, can also disrupt the gut microbiome. It is reported that shift workers have an altered gut microbiota compared to those with regular daytime schedules 26,28. These changes may contribute to an increased risk of metabolic disorders, gastrointestinal problems, and even certain types of cancer among shift workers 26,28–30.

The research is clear; we should prioritize sleep as an essential component of a healthy lifestyle. Adequate, restful sleep is crucial for maintaining a diverse and healthy gut microbiota, influencing our overall well-being2–7. Disruptions in sleep quality, reduced sleep hours, and shifted schedules can lead to imbalances in the gut microbiome, potentially contributing to various health issues 5,18,20,22,26. By adopting good sleep practices, managing stress levels, and establishing consistent sleep routines, we can support the health of our gut microbiome and promote overall wellness.

At Novel Biome, we believe in the importance of the gut microbiome for overall health and the possibilities of fecal microbiota transplantation (FMT) to restore gut health and treat disease. Novel Biome focuses on FMT product manufacturing and supplying high-quality products, relying on our world-class donors to allow us to make a significant difference in the lives of many individuals, take our eligibility quiz to see if you can be a stool donor. 

References: 1. Grosicki, G. J. et al. 2020, 2. Parkar, S. et al. 2019, 3. Smith, R. P. et al.  2019, 4. Wang, Y. et al. 2022, 5. Liu, B. et al. 2019, 6. Morwani-Mangnani, J. et al. 2022, 7. Valentini, F. et al. 2020, 8. Choi, H. H. & Cho, Y.-S. 2016, 9. Johnson, D. et al. 2020, 10. Lee, L.-H. et al. 2019, 11. Lee, M. & Chang, E. B. 2021, 12. Ser, H.-L. et al. 2021, 13. Ternes, D. et al. 2020, 14. Withrow, D. et al. 2021, 15. Xu, M.-Q. 2015, 16.  Zhang, Q. et al. 2021, 17.  Ko, C.-Y. et al. 2019, 18. Wang, Z. et al. 2021, 19. Anderson, J. R. et al. 2017, 20. Benedict, C. et al. 2016, 21. Li, Y., Hao, Y. et al. 2018, 22. Thaiss, C. A. et al. 2014, 23. Belkaid, Y. & Hand, T. W. 2014, 24. Vatanen, T. et al. 2016, 25. Wilson, B. C. et al. 2019, 26. Nobs, S. P. et al. 2019, 27. Liu, Z. et al. 2020, 28.  Mortaş, H.. et al. 2020, 29.  Reynolds, A. C. et al. 2017, 30.  Roman, P. et al. 2023.  
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